ABVD Chemotherapy regimen

adriamycin

The combination chemotherapy regimen known as ABVD consists of the following drugs:

A Typical ABVD Regimen (regimens should be tailored to the individual)

  • Cycle length: 28 days
  • Number of cycles: 4-8
  • Day 1 & 15: Doxorubicin and vinblastine (IV push), bleomycin (slow IV push)
  • Days 1-5: Dacarbazine (IV)

Vomit potential?

  • Day 1: Very high
  • Days 2-5: High
  • Day 14: Moderate
  • What ABVD is effective for and why

    Almost since it was first established in 1975, the ABVD regimen has been considered the 'gold standard' for the treatment of virtually all stages of Hodgkins lymphoma (especially early-stages) and it is currently regarded as such by highly influential guideline-setting groups including the National Comprehensive Cancer Network, the German Hodgkins Study Group, and the American Society of Clinical Oncology.

    ABVD Side effects

    While each patient will have his or her own experiences with the side effects of the ABVD regimen, it is not uncommon for patients to endure bruising, bleeding, anemia, fatigue, nausea and/or vomiting, hair loss, mouth sores, and peripheral neuropathy. These side effects should all subside when one is finished with the regimen. Patients are encouraged to report all side effects to their oncologist or oncology team.

    Because of the presence of bleomycin, patients with lung or renal impairment may be recommended against receiving ABVD.

    Sources

    • Boyiadzis, Michael M. et al. Hematology-Oncology Therapy. 2007. New York: McGraw Hill, Medical Publishing Division.
    • Perry, Michael C, Editor. Companion Handbook to the Chemotherapy Sourcebook. 1999. Baltimore; Williams & Wilkins.
    • National Comprehensive Cancer Network, Clinical Practice Guidelines in Oncology: Hodgkins lymphoma, V.2.2010

    Significant studies and papers relevant to ABVD


 

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